“Blastoid Development and Implantation” Featuring Dr. Nicolas Rivron
Dr. Nicolas Rivron is a Principal Investigator at the Institute of Molecular Biotechnology of the Austrian Academy of Sciences in Vienna. His group recreates embryonic development using mammalian stem cells in a dish to better understand the encoded principles of self-organization. He talks about and using them to study implantation. He also discusses differences in development between mice and humans, , and an .
Nicolas Rivron is a pioneer in the field of early embryo modeling using pluripotent stem cells. His lab has rapidly advanced the utilization of blastoid models to study early developmental processes and to push the frontiers of what's possible in modeling human reproduction.
Dr. Arun Sharma, host
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This Episode's Stem Cell Roundup:
- – A Phase I trial showed safety, tolerability, and an improvement in dyskinesia symptoms.
- – CRISPR-Cas9 disruption of the HBG1 and HBG2 gene promoters was an effective strategy for induction of fetal hemoglobin.
- – Epitope-edited CAR T cells were effective against patient-derived acute myeloid leukemia, B cell lymphoma, and acute T cell leukemia.
- – A new reprogramming strategy produces hiPSCs with similar epigenetic and functional profiles to human embryonic stem cells.
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