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This rabbit polyclonal antibody reacts with human, mouse, and rat chromogranin A, a secretory protein found in the cytoplasmic vesicles of neurons and endocrine cells. Use this polyclonal antibody in applications requiring detection of chromogranin A, such as western blotting (WB) assays and immunohistochemistry protocols (IHC-P). It has been verified for use with immunocytochemistry (ICC).

Proteolytic fragments of chromogranin A form functional peptides that help to maintain homeostasis through autocrine and paracrine processes. Chromogranin A and its derivatives play key roles in the inhibition of insulin and leptin secretion in the pancreas and adipocytes, respectively. In addition to its endocrine functions, chromogranin A modulates cardiovascular functions by inhibiting arterial vasoconstriction. Other post-translational derivatives of chromogranin A participate in inflammatory responses and display some potent antimicrobial activity against bacteria and fungi. Elevated measurements of plasma chromogranin A also serve as a biomarker for the diagnosis of neuroendocrine tumors.