Neural Induction and Differentiation of ESCs and iPSCs
Human pluripotent stem cells (hPSCs), including human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells, are self-renewing cells that have the potential to develop into cells of all three germ layers, including the ectoderm. The ectoderm gives rise to the neural tube which includes all cells of the central nervous system including the brain. Since human brain tissue is hard to come by ES and iPS cells hold tremendous potential as a more representative model for studying human neurological development and disease. Being able to generate patient-specific differentiated cells bridges the gap between studies using animal models and clinical research.
We've created these resources to support your hPSC-derived neurological development and disease research, and to give you a window into the exciting research being done by others in the field.
Brains in a Dish: Using Cerebral Organoids to Study Human Brain Development and Disease
What are ‘mini-brains’, and how are they being used to study neurological development and disease? Dr. Oliver Wüseke, who works with cerebral organoids as a PostDoc in the Knoblich Lab at IMBA Vienna, gives an overview of the cerebral organoid field and discusses different techniques and results emerging as researchers increasingly adopt cerebral organoid technology to study brain development and disease.
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Development of Simplified and Defined Cell Culture for Human Pluripotent Stem CellsHuman pluripotent stem cells (hPSCs) have the ability to generate all cell types in the human body and can be used in many applications in basic research and translational medicine, including disease modeling, drug screening and cell therapy. Maintenance of high quality hPSCs is dependent on consistent in vitro cell culture conditions and handling techniques. TeSR™-E8™ is a defined, xeno-free medium with a simple and published formula that was developed to meet the demands of a wide range of applications. The E8 culture system has been successfully used to derive and maintain hPSCs, and enzyme-free methods have also been developed for cell expansion and cryopreservation. More recently, defined differentiation conditions have also been established for specific lineages. These developments will provide an efficient and cost-effective E8 platform for the hPSC field. This webinar is presented by Dr. Guokai Chen at the University of Macau. -
How to Generate Neural Progenitor Cells from hPSCs Using STEMdiff™ Neural Induction MediumSTEMdiff™ Neural Induction Medium is a defined, serum-free and highly efficient medium for the differentiation of hESCs & iPSCs to NPCs
