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T Cell Therapy

Adoptive T cell therapy has brought excitement to immuno-oncology research and hope to cancer patients who are out of treatment options. The most popular form of T cell for therapy are chimeric antigen receptor (CAR) T cells. These cells are engineered to express a synthetic transmembrane receptors containing the variable domain of an antibody to redirect their specificity to recognize and eliminate cancer cells upon infusion in patients.

Below is a collection of scientific resources for your T cell therapy research.

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Products 1 to 12 of 24 total

  1. Transform Intracellular Delivery Using the CellPore™ Transfection System
    Transform Intracellular Delivery Using the CellPore™ Transfection System
    Intracellular delivery of molecules is a key step in biological research, but traditional transfection methods are often limited in their ability to efficiently deliver macromolecules across diverse cell types without altering cell phenotype and function. <br><br>Watch this on-demand webinar—originally presented as a workshop at AAI 2025—to learn how the CellPore™ Transfection System addresses these limitations by using mechanoporation to create transient membrane pores, enabling direct cytosolic delivery with high efficiency and cell viability.
  2. Key Regulatory Considerations for Moving Your Cell Therapy Research to the Clinic
    Key Regulatory Considerations for Moving Your Cell Therapy Research to the Clinic
  3. Raw Material Qualification
    Ancillary Material Qualification
  4. Non-Viral CRISPR Knock-In Anti-B7-H3 CAR-T Cells Are Amenable for Treatment of Subtypes of Small Cell Lung Cancer
    Non-Viral CRISPR Knock-In Anti-B7-H3 CAR-T Cells Are Amenable for Treatment of Subtypes of Small Cell Lung Cancer
    In this webinar, Scientist Vimal Keerthi discusses his work on identifying CD276 (B7-H3) overexpression in primary human SCLC and developing a non-viral CRISPR-Cas9 knock-in (CKI) based platform against B7-H3 to manufacture CAR T cells for the treatment of SCLC. He demonstrates the feasibility of this CAR T manufacturing platform and how this provides a blueprint for immediate clinical translation, overcoming the bottleneck of viral vector production.<br><br>This webinar is part of the “Translational T Cell Talks: Scaling for the Future” event hosted in collaboration with Scientist.com on June 11, 2024. <a href="/translational-t-cell-talks-2024">View the rest of the talks and read the Q&A transcripts.</a>
  5. Stroma-Free, Serum-Free Expansion and Differentiation of Hematopoietic Stem and Progenitor Cells to the T Cell Lineage
    Stroma-Free, Serum-Free Expansion and Differentiation of Hematopoietic Stem and Progenitor Cells to the T Cell Lineage
  6. Production of Chimeric Antigen Receptor T cells
    Production of Chimeric Antigen Receptor T Cells
    This free Nature Protocols Wallchart summarizes the processes involved in producing CAR T cells for therapy.
  7. Genome Editing of Human Primary T Cells
    Genome Editing of Human Primary T Cells Using CRISPR-Cas9
  8. Roundtable: Improving Collaboration Between Industry and Academia in the Field of CAR T Cell Therapy
    Roundtable: Improving Collaboration Between Industry and Academia in the Field of CAR T Cell Therapy
  9. Advances in Point-of-Care Cell Engineering—What Are You Feeding Your CAR T Cells?
    Advances in Point-of-Care Cell Engineering—What Are You Feeding Your CAR T Cells?
    In this webinar, Dr. Julian J. Lum discusses key factors to consider when choosing metabolic assays and how they can be used to assess cell function. Additionally, he discusses the metabolic characteristics of different commercially available cell culture media formulations as well as the importance of assessing the array of media products and their impact on metabolism.<br><br>This webinar is part of the “Translational T Cell Talks: Scaling for the Future” event hosted in collaboration with Scientist.com on June 11, 2024. <a href="/translational-t-cell-talks-2024">View the rest of the talks and read the Q&A transcripts.</a>
  10. Combining CAR T Cells with STING Agonists to Fight Solid Tumors
    Combining CAR T Cells with STING Agonists to Fight Solid Tumors
    In this webinar, Dr. Uslu describes how IMSA101 enhances CAR T function through STING agonist-induced IL-18 secretion and how these findings lay the foundation for advancing the combinatorial approach into a clinical setting.<br><br>This webinar is part of the “Translational T Cell Talks: Scaling for the Future” event hosted in collaboration with Scientist.com on June 11, 2024. <a href="/translational-t-cell-talks-2024">View the rest of the talks and read the Q&A transcripts.</a>
  11. Next-Generation Cell Isolation Solutions for T Cell Therapy Research
    Next-Generation Cell Isolation Solutions for T Cell Therapy Research
    Join this talk, presented by Dr. Amanda Durkin and Q&A guest Dr. Frann Antignano, to learn about ϳԹ’s cell isolation solutions for fast and easy T cell isolation. This presentation will also focus on large-scale research strategies by introducing our new mobilized leukopaks and feature the Easy 250 EasySep™ Magnet—a scalable and efficient system for manual column-free isolation.<br><br>This webinar is part of the “Translational T Cell Talks: Scaling for the Future” event hosted in collaboration with Scientist.com on June 11, 2024. <a href="/translational-t-cell-talks-2024">View the rest of the talks and read the Q&A transcripts.</a>
  12. Next-Generation Tools to Advance Your Human T Cell Research
    Next-Generation Tools to Advance Your Human T Cell Research
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